Multiscale Modeling of Malaria
نویسنده
چکیده
Parasitic infectious diseases like malaria and certain hereditary hematologic disorders are often associated with major changes in the shape and viscoelastic properties of red blood cells. Such changes can disrupt blood flow and, possibly, brain perfusion, as in the case of cerebral malaria. In recent work on stochastic multiscale models—in conjunction with large-scale parallel computing—we were able to quantify, for the first time, the main biophysical characteristics of malaria, i.e., the dynamics and microrheology of malaria-infected blood flow in capillaries and small arteries. The same computational framework can be applied to other blood diseases, including sickle cell anemia and diabetes.
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